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姓名：史铠 性别：男 职称：副教授 Email: shikai9901@163.com |
2010.09-2014.06 乐山师范学院化学学院应用化学专业，本科生；
2014.09-2017.06 西南大学化学化工学院分析化学专业，硕士研究生;
（导师：向云）
2017.09-2021.06 湖南大学化学化工学院化学专业，博士研究生;
（导师：聂舟、雷春阳、黄燕）
2021.07-2023.11 乐山师范学院新能源与化学学院，讲师；
2023.12-至今 乐山师范学院新能源与化学学院，副教授；
《Frontiers in Physiology》和《Environmental Science: Water Research & Technology》期刊审稿人
分子识别与化学生物传感器开发
1. 基于CRISPR-Cas12a与核酸电路的便携式定量检测新方法在食品检测中的应用研究，国家自然科学基金委员会, 青年科学基金项目
2. 基于DNA分子机器与CRISPR-Cas12a耦合用于肺癌相关miRNAs的精准诊断，四川省科学技术厅，苗子工程
3. 基于CRISPR/Cas12a作为信号扩增技术对癌症标志物的精准诊断，乐山市重点科技项目
一、以第一作者或通讯作者身份发表论文
1. Phosphorothioate-modified G-quadruplex as a signal-on dual-mode reporter for CRISPR/Cas12a-based portable detection of environmental pollutants, Analytica Chimica Acta, 2024, 1308, 342649.
2. Hg2+-triggered cascade strand displacement assisted CRISPR-Cas12a for Hg2+ quantitative detection using a portable glucose meter, Analytica Chimica Acta, 2023, 1278, 341756.
3. PAM-free cascaded strand displacement coupled with CRISPR-Cas12a for ampliffed electrochemical detection of SARS-CoV-2 RNA, Analytical Biochemistry, 2023, 664, 115046.
4. A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics, Science Advances, 2021, eabc7802.
5. Amplified and label-free electrochemical detection of a protease biomarker by integrating proteolysis-triggered transcription, Biosensors and Bioelectronics, 2021, 190, 113372.
6. Coupling of proteolysis-triggered transcription and CRISPR-Cas12a for ultrasensitive protease detection, Science China Chemistry, 2021, 64: 330-336.
7. Target-triggered catalytic hairpin assembly and TdT-catalyzed DNA polymerization for amplified electronic detection of thrombin in human serums, Biosensors and Bioelectronics, 2017, 87: 495-500.
8. Cascaded strand displacement for non-enzymatic target recycling amplification and label-free electronic detection of microRNA from tumor cells. Analytica Chimica Acta, 2016, 916: 1-7.
9. DNA-fueled molecular machine enables enzyme-free target recycling amplification for electronic detection of microRNA from cancer cells with highly minimized background noise. Analytical chemistry, 2015, 87(16):8578-8583.
10. Toehold链置换辅助智能手机比色法特异性检测废水中新冠病毒靶标RNA, 分析试验室，2024，43，36-41
11. CRISPR/Cas技术在核酸检测中的应用进展，分析测试学报，2018，37 (10):4
二、授权专利
聂舟，史铠，雷春阳，基于CRISPR-Cas自催化放大网络的核酸检测方法及其应用
